Research RA Treatment Advances While there is still no cure for rheumatoid arthritis (RA), great strides have been made in RA research over the last 2 decades. It's important to keep up with these developments and ask your rheumatologist about their potential. Since the 1980s, disease-modifying antirheumatic drugs (DMARDs) have been the standard among RA treatments because they do more than just treat symptoms. They can actually slow the development of RA. In the 1990s, a new type of DMARD called biologic DMARDs was introduced. Many of these treatments target a chemical in the immune system called tumor necrosis factor (TNF), which is directly involved in the inflammation of RA. These drugs are known as anti-TNFs (also called TNF inhibitors). Today, many rheumatologists have been using a combination of treatments to account for the different ways that RA can affect you. One particular treatment that has shown great promise is called targeted B-cell therapy. To learn more about targeted B-cell therapy, click here. Next Target Your B-cells

RISE is brought to you by the makers of Rituxan^® (rituximab).

INDICATION AND IMPORTANT SAFETY INFORMATION
Rituxan^® (rituximab), in combination with methotrexate, is indicated to reduce signs and symptoms and to slow the progression of structural damage in adult patients with moderately-to-severely active rheumatoid arthritis (RA) who have had an inadequate response to one or more TNF antagonist therapies.

Rituxan can cause the following serious side effects, some of which could be life threatening: progressive multifocal leukoencephalopathy (PML), infusion reactions, tumor lysis syndrome (TLS), and severe skin reactions. Other serious side effects with Rituxan include hepatitis B virus reactivation, heart problems, infections, and stomach and bowel problems. Common side effects during Rituxan infusions include fever, headache, chills and shakes, nausea, itching, hives, cough, sneezing, and throat irritation or tightness. If you experience any symptoms or side effects during or after Rituxan treatment, seek immediate medical attention.

Please see full Prescribing Information, including Medication Guide.