RISE is brought to you by the makers of Rituxan^® (rituximab).

INDICATION AND IMPORTANT SAFETY INFORMATION
Rituxan^® (rituximab), in combination with methotrexate, is indicated to reduce signs and symptoms and to slow the progression of structural damage in adult patients with moderately-to-severely active rheumatoid arthritis (RA) who have had an inadequate response to one or more TNF antagonist therapies.

Rituxan can cause the following serious side effects, some of which could be life threatening: progressive multifocal leukoencephalopathy (PML), infusion reactions, tumor lysis syndrome (TLS), and severe skin reactions. Other serious side effects with Rituxan include hepatitis B virus reactivation, heart problems, infections, and stomach and bowel problems. Common side effects during Rituxan infusions include fever, headache, chills and shakes, nausea, itching, hives, cough, sneezing, and throat irritation or tightness. If you experience any symptoms or side effects during or after Rituxan treatment, seek immediate medical attention.

Please see full Prescribing Information, including Medication Guide.